Characterization of Lewy body pathology in 12‐ and 16‐year‐old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease
Identifieur interne : 001E03 ( Main/Exploration ); précédent : 001E02; suivant : 001E04Characterization of Lewy body pathology in 12‐ and 16‐year‐old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease
Auteurs : Jia-Yi Li [Suède] ; Elisabet Englund [Suède] ; H Kan Widner [Suède] ; Stig Rehncrona [Suède] ; Anders Björklund [Suède] ; Olle Lindvall [Suède] ; Patrik Brundin [Suède]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-06-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Aggregation, Anatomic pathology, Fetal Tissue Transplantation (methods), Graft, Human, Humans, Lewy Bodies (metabolism), Lewy Bodies (pathology), Lewy Bodies (ultrastructure), Lewy body, Longitudinal Studies, Male, Mesencephalon (cytology), Microscopy, Electron, Transmission (methods), Middle Aged, Nervous system diseases, Neurons (metabolism), Neurons (pathology), Neurons (ultrastructure), Parkinson Disease (pathology), Parkinson Disease (surgery), Parkinson disease, Postmortem Changes, Protein, Thiazoles (diagnostic use), Time Factors, Transplantation, alpha-Synuclein (metabolism), neural transplantation, protein aggregation, transmissible neurological disease, α‐synuclein.
- MESH :
- chemical , diagnostic use : Thiazoles.
- cytology : Mesencephalon.
- metabolism : Lewy Bodies, Neurons, alpha-Synuclein.
- methods : Fetal Tissue Transplantation, Microscopy, Electron, Transmission.
- pathology : Lewy Bodies, Neurons, Parkinson Disease.
- surgery : Parkinson Disease.
- ultrastructure : Lewy Bodies, Neurons.
- Humans, Longitudinal Studies, Male, Middle Aged, Postmortem Changes, Time Factors.
Abstract
We previously reported the occurrence of Lewy bodies in grafted human fetal mesencephalic neurons in two patients with Parkinson's disease. Here, we have used immunohistochemistry and electron microscopy to characterize the development of Lewy bodies in one of these cases. This patient was operated in putamen on both sides at 12 or 16 years before death, respectively. We demonstrate that 2% of the 12‐year‐old and 5% of the 16‐year‐old grafted, presumed dopaminergic neurons contained Lewy bodies immunoreactive for α‐synuclein. Based on morphological analysis, two forms of α‐synuclein‐positive aggregates were distinguished in the grafts, the first a classical and compact Lewy body, the other a loose meshwork aggregate. Lewy bodies in the grafts stained positively for ubiquitin and thioflavin‐S, and contained characteristic α‐synuclein immunoreactive electron dense fibrillar structures on electron microscopy. Our data indicate that Lewy bodies develop gradually in transplanted dopaminergic neurons in a fashion similar to that in dopaminergic neurons in the host substantia nigra. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.23012
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-06-15">2010-06-15</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1091">1091</biblScope><biblScope unit="page" to="1096">1096</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">B5D6012E0146DB9DF46F3ADE7C619D7B14E86D20</idno><idno type="DOI">10.1002/mds.23012</idno><idno type="ArticleID">MDS23012</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aggregation</term><term>Anatomic pathology</term><term>Fetal Tissue Transplantation (methods)</term><term>Graft</term><term>Human</term><term>Humans</term><term>Lewy Bodies (metabolism)</term><term>Lewy Bodies (pathology)</term><term>Lewy Bodies (ultrastructure)</term><term>Lewy body</term><term>Longitudinal Studies</term><term>Male</term><term>Mesencephalon (cytology)</term><term>Microscopy, Electron, Transmission (methods)</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Neurons (metabolism)</term><term>Neurons (pathology)</term><term>Neurons (ultrastructure)</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (surgery)</term><term>Parkinson disease</term><term>Postmortem Changes</term><term>Protein</term><term>Thiazoles (diagnostic use)</term><term>Time Factors</term><term>Transplantation</term><term>alpha-Synuclein (metabolism)</term><term>neural transplantation</term><term>protein aggregation</term><term>transmissible neurological disease</term><term>α‐synuclein</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Thiazoles</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Mesencephalon</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lewy Bodies</term><term>Neurons</term><term>alpha-Synuclein</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Fetal Tissue Transplantation</term><term>Microscopy, Electron, Transmission</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lewy Bodies</term><term>Neurons</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Lewy Bodies</term><term>Neurons</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Postmortem Changes</term><term>Time Factors</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Agrégation</term><term>Anatomopathologie</term><term>Corps Lewy</term><term>Greffe</term><term>Homme</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Protéine</term><term>Transplantation</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We previously reported the occurrence of Lewy bodies in grafted human fetal mesencephalic neurons in two patients with Parkinson's disease. Here, we have used immunohistochemistry and electron microscopy to characterize the development of Lewy bodies in one of these cases. This patient was operated in putamen on both sides at 12 or 16 years before death, respectively. We demonstrate that 2% of the 12‐year‐old and 5% of the 16‐year‐old grafted, presumed dopaminergic neurons contained Lewy bodies immunoreactive for α‐synuclein. Based on morphological analysis, two forms of α‐synuclein‐positive aggregates were distinguished in the grafts, the first a classical and compact Lewy body, the other a loose meshwork aggregate. Lewy bodies in the grafts stained positively for ubiquitin and thioflavin‐S, and contained characteristic α‐synuclein immunoreactive electron dense fibrillar structures on electron microscopy. Our data indicate that Lewy bodies develop gradually in transplanted dopaminergic neurons in a fashion similar to that in dopaminergic neurons in the host substantia nigra. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Suède</li></country></list><tree><country name="Suède"><noRegion><name sortKey="Li, Jia I" sort="Li, Jia I" uniqKey="Li J" first="Jia-Yi" last="Li">Jia-Yi Li</name></noRegion><name sortKey="Bjorklund, Anders" sort="Bjorklund, Anders" uniqKey="Bjorklund A" first="Anders" last="Björklund">Anders Björklund</name><name sortKey="Brundin, Patrik" sort="Brundin, Patrik" uniqKey="Brundin P" first="Patrik" last="Brundin">Patrik Brundin</name><name sortKey="Englund, Elisabet" sort="Englund, Elisabet" uniqKey="Englund E" first="Elisabet" last="Englund">Elisabet Englund</name><name sortKey="Lindvall, Olle" sort="Lindvall, Olle" uniqKey="Lindvall O" first="Olle" last="Lindvall">Olle Lindvall</name><name sortKey="Lindvall, Olle" sort="Lindvall, Olle" uniqKey="Lindvall O" first="Olle" last="Lindvall">Olle Lindvall</name><name sortKey="Rehncrona, Stig" sort="Rehncrona, Stig" uniqKey="Rehncrona S" first="Stig" last="Rehncrona">Stig Rehncrona</name><name sortKey="Widner, H Kan" sort="Widner, H Kan" uniqKey="Widner H" first="H Kan" last="Widner">H Kan Widner</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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